European Respiratory Journal (ERJ) - Archive
| August (Issue 2 Volume 36) |  |
| CC chemokine receptor 5 gene polymorphisms in beryllium disease
Sato H., Silveira L., Spagnolo P., Gillespie M., Gottschall E.B., Welsh K.I., Du Bois R.M., Newman L.S., Maier L.A. Eur Respir J 2010; 36: 331 |  |  |  | | | | | | | | |
Abstract| CC chemokine receptor 5 (CCR5) is expressed on type-1 T-helper cells, which are involved in the pathogenesis of the granulomatous lung disease chronic beryllium disease (CBD). CCR5 gene (CCR5) polymorphisms are associated with sarcoidosis severity. The present study explores associations between CCR5 polymorphisms and CBD and its disease progression.Eight CCR5 polymorphisms were genotyped in CBD (n = 88), beryllium sensitisation (BeS; n = 86) and beryllium-exposed nondiseased controls (n = 173)... [View all] |
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