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 European Respiratory Journal (ERJ) - Archive

June (Issue 6 Volume 35)
1370
Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux
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Cui Y., Devillier P., Kuang X., Wang H., Zhu L., Xu Z., Xia Z., Zemoura L., Advenier C., Chen H.
Eur Respir J 2010; 35: 1370-1376		Full textPDF-fileAbstract

Abstract
Gastro-oesophageal reflux is frequent in chronic airway diseases and is considered a trigger for symptoms. In animal models, bilateral vagotomy or muscarinic antagonists prevent the increase in airway resistance and the microvascular leakage induced by acute oesophageal acid instillation. The present study investigates lung inflammation and remodelling in an animal model of chronic gastro-oesophageal reflux disease (GORD), and the effectiveness of pretreatments with tiotropium, atropine and dex... [View all]
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