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 European Respiratory Journal (ERJ) - Archive

January (Issue 1 Volume 35)
176
Bleomycin induces pleural and subpleural fibrosis in the presence of carbon particles
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Decologne N., Wettstein G., Kolb M., Margetts P., Garrido C., Camus P., Bonniaud P.
Eur Respir J 2010; 35: 176-185		Full textPDF-fileAbstract

Abstract
The pathological changes in idiopathic pulmonary fibrosis (IPF) typically start in subpleural lung regions, a feature that is currently not explained. IPF, as well as bleomycin-induced lung fibrosis, are more common in smokers. We hypothesised that carbon particles, which are major components of cigarette smoke that are transported to alveoli and pleural surface, might be involved in the development of subpleural fibrosis through interaction with pleural mesothelial cells. Carbon particles were... [View all]
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