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 European Respiratory Journal (ERJ) - Archive

February (Issue 2 Volume 33)
252
Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
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Naura A. S., Datta R., Hans C. P., Zerfaoui M., Rezk B. M., Errami Y., Oumouna M., Matrougui K., Boulares A. H.
Eur Respir J 2009; 33: 252-262		Full textPDF-fileAbstract

Abstract
Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease. The present study investigated the role of iNOS in ovalbumin-induced eosinophilia from the perspective of its relationship with poly(ADP-ribose) polymerase-1 (PARP-1) and oxidative DNA damage. A mouse model of ovalbumin-induced eosinophilia was used to conduct the studies. iNOS-associated protein ni... [View all]
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