ERS Research Seminar: Optimising models for human lung diseases and drug development, Paris 2013

About
Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.
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Background

Animal models, organ and cell cultures are critical to understand mechanisms and pathogenesis of pulmonary health and disease, and are indispensable in drug development. However, the pathogenetic and translational relevance of the models is often unclear. Further, the use of animals in medical research is becoming increasingly controversial from an ethical perspective.

The objectives of this seminar were to gather respiratory scientists and clinicians from different subspecialties to foster exchange and increase their knowledge about lung disease models. It is expected that better understanding of the available models, especially their benefits and their limitations, will facilitate better use of research resources and reduce the numbers of animals in pulmonary research, thereby enhancing the ethical standards of experimental pulmonary research.

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 [+]  Slide presentation Animal models in drug development
B. Crestani (Paris, France)
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 [+]  PDF journal article, handout or slides Slide presentation Modeling in vitro, ex vivo or in vivo?
P. Mercer (London, United Kingdom)
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 [+]  Slide presentation Standardisation of animal models across centers - scientific necessity or ethical mandate?
E. White (Ann Arbor, United States of America)
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 [+]  PDF journal article, handout or slides Slide presentation Ins and outs of transgenic animals
W. Shi (Los Angeles, Ca, United States of America)
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Functional assessment in small animals
J. Hamacher (Bern, Switzerland)
 [+]  PDF journal article, handout or slides Morphometry and Stereology in lung tissue
H. Fehrenbach (Borstel, Germany)
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 [+]  PDF journal article, handout or slides Slide presentation Small animal imaging using CT, PET and MRI
R. Labiris (Hamilton - Ontario, Canada)
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 [+]  PDF journal article, handout or slides Slide presentation Microscopic Imaging of the lungs and other approaches to assess vascular permeability
W. Kuebler (Toronto, Canada)
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 [+]  PDF journal article, handout or slides Slide presentation Pulmonary fibrosis and ILD
P. Bonniaud (Dijon, France)
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 [+]  PDF journal article, handout or slides 10 Acute lung injury
S. Uhlig (Aachen, Germany)
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 [+]  PDF journal article, handout or slides Slide presentation 11 Acute and Chronic models for asthma/COPD
G. Joos (Ghent, Belgium)
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 [+]  PDF journal article, handout or slides Slide presentation 12 Pulmonary Hypertension
C. Guignabert (Creteil, France)
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13 Bacterial and viral infections
M. Witzenrath (Berlin, Germany)