ERS Research Seminar: Metabolic Aspects of the Obstructive Sleep Apnea Syndrome (OSAS), Düsseldorf 2007

About
Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.
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Background

Insulin resistance is often associated with obstructive sleep apnoea syndrome (OSAS) and could contribute to cardiovascular risk in OSAS. Sleep loss and intermittent hypoxia could contribute to the pathogenesis of the metabolic alterations associated with obesity, a common feature of OSAS. The biology of the adipocyte is being increasingly studied, and it has been found that hypoxia negatively affects adipocyte function.

This Research Seminar aimed at discussing:

  • the effects of hypoxia on glucose metabolism and adipocyte function
  • the role of inflammatory activation in OSAS and obesity
  • the alarming rates of obesity and OSAS in children
  • the harmful effects of the metabolic syndrome in OSAS
  • the effects of OSAS treatment on metabolic variables
  • the relationship between daytime sleepiness and hormonal and inflammatory responses.
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 [+]  PDF journal article, handout or slides Slide presentation Metabolic effects of OSAS and cardiovascular risk
M. Bonsignore (Palermo, Italy)
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 [+]  PDF journal article, handout or slides Slide presentation Is OSAS a systemic disease?
A. Vgontzas (Hershey, Pa, United States of America)
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Lack of sleep as a risk factor for obesity
K. Spiegel (Brussels, Belgium)
 [+]  PDF journal article, handout or slides Obesity in children: a model for early aspects and prevention of OSAS
W. Kiess (Leipzig, Germany)
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 [+]  Slide presentation Sleep-disordered breathing and metabolic alterations in children
S. Verhulst (Wilrijk, Belgium)
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 [+]  PDF journal article, handout or slides Can CPAP reduce adverse cardiovascular and metabolic effects of OSAS?
R. Tkacova (Kosice, Slovakia)
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 [+]  PDF journal article, handout or slides Endocrine function of adipose tissue
P. Trayhurn (Liverpool, United Kingdom)
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 [+]  PDF journal article, handout or slides Adipose tissue and muscle insulin resistance
J. Eckel (Duesseldorf, Germany)
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 [+]  PDF journal article, handout or slides Inflammation and vascular dysfunction
B. Staels (Lille, France)
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 [+]  PDF journal article, handout or slides Slide presentation 10 Biological Specificity of Visceral Adipose Tissue and Therapeutic Intervention
F. Giorgino (Bari, Italy)
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11 Early alterations of protein expression in adipose tissue of obese subjects
D. Gasperikova (Bratislava, Slovakia)
 [+]  PDF journal article, handout or slides Slide presentation 12 Intermittent hypoxia in sleep apnea: a cause of inflammatory activation
W. McNicholas (Dublin, Ireland)
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 [+]  Slide presentation 13 Biology of peripheral blood inflammatory cells in OSAS
L. Lavie (Haifa, Israel)
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 [+]  PDF journal article, handout or slides Slide presentation 14 Excessive daytime somnulence, obesity and inflammation
A. Vgontzas (Hershey, Pa, United States of America)
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 [+]  PDF journal article, handout or slides Slide presentation 15 The development of insulin resistance in a murine model of intermittent hypoxia
C. O'Donnell (Pittsburgh, United States of America)
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16 Differential regulation of glucose homeostasis by acute sleep fragmentation
M. Dematteis (Grenoble, France)