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ERS Research Seminar on Adaptations to Hypoxia, Palermo 2005
Research Seminar  
RESEARCH SEMINARS 
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  Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.
 
   
   
         

Background:

Basic research has started unravelling the biology of gene regulation in response to hypoxia. In addition, the hypoxic stimulus appears to exert different effects according to the way it is delivered (continuous vs. intermittent hypoxia).  This new information is very important for clinicians, especially those dealing with respiratory insufficiency and sleep disordered breathing, but also for exercise and high-altitude physiologists. The purpose of this Research Seminar is to fill the gap between basic and clinical science by gathering experts from different research fields (cell biology, exercise, high altitude medicine, clinical respiratory research).  A large amount of time will be dedicated to discussion, with special focus on the potential impact of recently described cell mechanisms for diagnosis and treatment of respiratory disease.


 
 [+]  PDF journal article, handout or slides Slide presentation
Introduction: Oxygen transport and oxygen utilisation: an integrated view
P. D. Wagner (La Jolla, United States of America)
 [+]  PDF journal article, handout or slides
HIF Gene expression and Hypoxia signalling
J. Pouysségur (Nice, France)
 [+]  PDF journal article, handout or slides Slide presentation
Acute hypoxia signaling in the carotid body: role of 02-sensitive ion channels
J. Lopez-Barneo (Seville, Spain)
 [+]  PDF journal article, handout or slides Slide presentation
Disruption of the HIF-1 pathway in cancer cells
L. Poellinger (Stockholm, Sweden)
 [+]  Slide presentation
Neurobehavioural consequences of intermittent hypoxia
B. Row (Louisville, United States Of America)
 [+]  PDF journal article, handout or slides Slide presentation
Impact of intermittent hypoxia on cardiovascular morbidity and mortality
A. Agusti (Palma de Mallorca, Spain)
 [+]  PDF journal article, handout or slides Slide presentation
Hypoxia and the bone marrow
M. Bonsignore (Palermo, Italy)
 [+]  PDF journal article, handout or slides Slide presentation
Pulmonary vascular remodeling and stem cells
N. Voelkel (Denver, Co, United States Of America)
 [+]  PDF journal article, handout or slides
Adaptation of VO2, oxygen sensing and ROS signalling during hypoxia
P. Schumacker (Chicago, United States Of America)
 [+]  Slide presentation 10 
Nutriotional problems in COPD: interference of hypoxia with the energetic metabolism
A. Schols (Maastricht, The Netherlands)
 [+]  PDF journal article, handout or slides Slide presentation 11 
Muscle dysfunction in COPD
A. Agusti (Palma De Mallorca, Spain)
 [+]  PDF journal article, handout or slides 12 
Oxygen sensing in the pulmonary circulation
P. Schumacker (Chicago, United States Of America)
 [+]  PDF journal article, handout or slides 13 
Hypoxic and non-hypoxic induction mechanisms of HIF-1alpha
J. Pouysségur (Nice, France)