Abstract
A recap of the first Breathe online journal club by @fritsfranssen http://ow.ly/5uXX308xAG1
On December 13, 2016, the first Breathe journal club took place. During the annual ERS International Congress in London, UK, in September 2016, the Breathe editorial board agreed to set up this event. In the journal club, a recently published research article from another journal, in keeping with the thread of the current Breathe issue, is presented, supported by multimedia slides, in about 20 min by an expert in this field who is not an author of the paper. Afterwards, the paper is further discussed. The authors of the paper are available to explain their work, provide deeper insight in their results, talk about the clinical and scientific consequences of their study, and elaborate on future plans. This discussion is chaired by another expert in the specific field of interest, who is not directly involved in the present study. Participants to the journal club can submit questions and comments related to the paper and presentation during the entire course of the event, and in this way are actively involved in the discussion. Depending on the degree of interaction and discussion, the journal club ultimately lasts for 60 min.
In its inaugural edition, David Berlowitz (University of Melbourne, Melbourne Australia) presented a recent publication by Jesus Gonzalez-Bermejo (Sorbonne Universités, Paris, France) and his colleagues of the RespiStimALS study group that was published in Lancet Neurology [1]. In this multicentre, randomised, controlled, triple-blind trial, GONZALEZ-BERMEJO et al. [1] investigated whether early diaphragm pacing could slow down diaphragm deterioration and would therefore delay the need for noninvasive ventilation in amyotrophic lateral sclerosis (ALS) patients with moderate respiratory involvement. All patients received phrenic stimulators by laparoscopic intervention and were randomly assigned to receive either active or sham stimulation. As presented by Dr Berlowitz during the journal club, unplanned masked analysis was performed after another trial showed excess mortality with diaphragm pacing in ALS patients with hypoventilation [2]. As this analysis revealed excess all-cause mortality in the active stimulation group, RespiStimALS was terminated and the authors concluded that diaphragm pacing is not indicated at the early stage of ALS-related respiratory involvement. During the online discussion, which was led by Richard Lewis (Cedars-Sinai Medical Center, Los Angeles, CA, USA), Dr Gonzalez-Bermejo explained that aspiration and acute respiratory events are among the potential mechanisms related to the increased mortality risk with diaphragm pacing. Subsequently, Dr Gonzalez-Bermejo responded to the comments and questions submitted by the online participants. Once again, I would like to thank the three professional experts from all over the world for their outstanding contributions and the pioneering participants for their active involvement.
The Breathe journal club initiative offers several unique opportunities. In addition to being informed about a recent and relevant publication in the field of respiratory medicine, participants have to possibility to directly interact with worldwide experts from their “safe” home or work environment. They are updated beyond the text presented in the publication and may be inspired by the discussion in ways relating to their own clinical or scientific work. Events are scheduled well in advance in order for participants to fit these in their busy agendas. Free registration is offered and the event is accessible for non-ERS members as well. For those not able to join the live session, a recording of the journal club is posted online. Finally, the possibility of gaining CME credits for journal club participation is currently being explored by the Breathe editorial board.
Did you miss the first Breathe journal club? Catch up at http://ers.adobeconnect.com/p56j4rsbeqb
I hope that you share my enthusiasm about the journal club and that many Breathe readers will participate in the next one, which is scheduled for March 7, 2017, at 18:00 CET.
To register for the next Breathe journal club, please complete the form at https://goo.gl/forms/rcR5jtg2sqkttph12
In this edition, we will discuss a paper on predictors of all-cause mortality in patients with severe chronic obstructive pulmonary disease and major depression admitted to a rehabilitation hospital.