Abstract
Introduction: Sleep/awake homeostasis has a major role in insulin production and blood glucose control. Several studies propose that sleep disturbances are associated with an increased risk of type 2 Diabetes Mellitus (DM2).Objective: To compare sleep measures between patients with and without DM2.Methods: Retrospective analysis using data from polysomnographic recordings obtained at the pulmonology department of CHBV since 2011 to 2014. Sleep measures [total sleep time (TST); sleep efficiency (SE); time spent on each sleep stage], respiratory parameters [apnea/hipopnea index (AHI); oxygen desaturation index (ODI); average peripheral oxygen saturation (SpO2)] and data on demographics and medical history were collected. The association between DM2 and sleep measures was estimated using Mann-Whitney tests or t-tests. Linear regression model was performed taking into account other demographic and clinical characteristics.Results: Four hundred ninety nine patients were included (mean age 54.3±12,46; 68,3% male). Among these 81 patients (16,2%) had DM2 which was associated with decreased TST, SE, slow wave and REM sleep but with no statistically significant differences. In univariate analysis DM2 was associated with lower SpO2, higher AHI, and ODI, which was statistically significant (p<0.005), but this association was lost when we adjust it to other clinical co-morbidities (arterial hypertension, dislipidemia) and body mass index.Conclusion: Our results reveal an association of sleep disordered breathing and DM2, however this association seems to be only a piece of an intricate puzzle that includes other metabolic and cardiovascular disorders that perhaps share stronger risk factors such as obesity/overweight.