Abstract
Objective: to study pulmonary diffusing capacity (DLCO) and the risk of fractures in patients with chronic obstructive pulmonary disease (COPD).Material and Methods:125 patients with chronic obstructive pulmonary disease (COPD) were observed. The investigated group was made by the men having the long experience of smoking. Smoker index was 240. The average age was 61.4 ± 6.4 years. The patients received basic therapy system glucocorticoids have been excluded from the research. Research of function of external breath was studied with multimodular installation of type «Master-Lab/Jaeger». Pulmonary diffusing capacity (DLCO) was studied. Research of mineral density of a bone fabric was studied with the method x-ray absorbtiometry with the densitometer « Lunar DPX-NT». The assessment of risk of osteoporotic fractures were calculated by means of the computer program FRAX.Results:The patients were divided into 3 groups: DLCO <40%, DLCO 40-60%, DLCO> 60%. The high risk of hip fracture (> 3) in program FRAX was detected in 62.5% of patients with a sharp decrease of DLCO <40%. In the group of patients with DLCO 40-60% the high risk of hip fracture was diagnosed in 29.62% of patients. In the group of patients with DLCO> 60% the high risk of hip fracture was detected in 24.24% of patients. The correlation coefficient between DLCO / VA and the risk of hip fracture was r -0,44 (p <0.05).Conclusions:decrease of pulmonary diffusing capacity has an important role in the progression of the risk of fractures in patients with COPD.