Abstract
Objectives:This project aimed to Study the correlation between inflammatory cytokines and the dynamic change of sIgE and sIgG4 of Der p, Der p1 and Der p2(3 allergens)during Specific immunotherapy (SIT).Methods:Serum inflammatory cytokines and 3 allergens were analyzed from 55 patients with asthma and/or rhinitis SIT.the level of eight kinds of inflammatory cytokines 8 were detected, therefore, the dynamic change & correlation of house dust mites and its components-sIgE and sIgG4 of Der p1 and Der p2 were analyzed.Results:There was no significant difference in eight kinds of inflammatory cytokines before and after SIT.Before treatment,there was a correlation in level of IL-5 secreted by Th2 ,level of Der p-IgE,Der p-IgG4 and level of Der p2-IgG4.After17W, there were correlations in IL-5 & Der p2-IgE and three kinds of allergenslevel of IgG4,IL-17 and IgG4 of three kinds of allergens,level of Der p2-IgE and IFN-g secreted by Th1.After57W,there were correlations in IL-5 and Der p-IgE,Der p1-IgE and Der p1-IgG4,level of IL-8 and level of IgG4.From 0-17 W,there was positive correlation in the increasing range of house dust mites'components- sIgG4 of Der p1&Der p2 and the D-value of IL-5&IL-17 before and after treatment.Moreover,from 17 to 57 weeks,there was negative correlation in the increasing range of sIgG4 of Der p & Der p2 and the D-value of TNF-a before and after treatment.Conclusions:SIT was a dynamic immune process and with the process of SIT,immune status of SIT was reflected by house dust mites and its main components-IgE&IgG4of Der p1&Der p2 in clinic detection.