Abstract
We aimed to study the changes in spirometric indices and quality of life of smoker and non-smoker COPD subjects over a period of 1 year. Methods: Physician confirmed 71 NS-COPD subjects, 54 S-COPD subjects underwent pre-post bronchodilator spirometry, SGRQ and CAT questionnaires administration at baseline and after 1 year of follow up. 100 healthy individuals were followed up for one year with pre-post spirometry as control population. Results: Mean (±SD) pre-bronchodilator FEV1 (L), FVC (L) values at baseline and change after 1 year for healthy, S-COPD and NS-COPD are mentioned in Table 1.

Table 1
 Healthy (n=100)S-COPD (n=54)NS-COPD(n=71)
M:F and (Mean ± SD Age in yrs)55:45 (64.0 ± 7.4)54:0 (66.9 ± 7.5)30:41 (63.8 ± 8.1)
FEV1 baseline (L) Mean ± SD1.94 ± 0.430.96 ± 0.380.78 ± 0.31
FVC baseline (L) Mean ± SD2.46 ± 0.581.80 ± 0.551.47 ± 0.49
D FEV1 Pre (ml): Mean (CI)-7.7 (-40.9, +25.4)-27.7 (-84.6, +29.1)+48.1 (+0.93, +95.3)
D FVC Pre (ml): Mean (CI)+8.8 (-38.4, +56.1)-49.2 (-150.8, +52.2)+22.0 (-60.4, +104.4)
D SGRQ Total: Mean (CI)NA+0.2 (-5.9, +6.4)+2.3 (-3.2, +7.8)
D CAT: Mean (CI)NA+4.5 (+2.4, +6.6)*+4.8 (+2.7, +6.9)*

Female NS-COPD subjects tended to show worse lung function, and had significantly worse quality of life compared to male NS-COPD subjects as assessed by CAT scores. Conclusion: NS-COPD subjects had lower baseline lung function values than S-COPD. FEV1 and FVC values declined significantly in S-COPD subjects and increased in NS-COPD subjects after 1year, although both had similar decrements in quality of life.