Abstract
The aim of study was to evaluate the diagnostic significance of plasma SPD and CRP in patients with LRTI.
Study population. 4 patients with COPD acute exacerbations (AE COPD), 8 patients with community acquired pneumonia (P) and 10 healthy persons (H) made the study sample.
Methods. Plasma CRP and SPD were measured in addition to physical examination, spirometry and chest X-Ray.
Results are shown in table 1.
GroupsSPD, Me [25-75%] ng/mlCRP, mg/l Me [25-75%]
AE COPD833.65 [721.00-1121.80]#, $7,14 [5,89-26.60]##, $$
P455.55 [275.20-560.05]*,79,85 [32,85-189.00] ]**
H280.00 [232.00-407,13]5,50 [5,42-5.78]
# pAE COPD-P= 0.017; $ pAE COPD-H = 0.005; * pP-H = 0.28; ## pAE COPD-P = 0.027; $$ pAE COPD-H = 0.024; ** pP-H =0.001There was no any correlation between SPD and CRP either in patients with AE COPD, or in H (R = -0.4, p = 0.6; R = -0.47, p = 0.16 respectively). But SPD significantly correlate with CRP in patients with P (R = 0.8, p = 0.01).
Conclusions: 1) Both SPD and CRP increases in patients with LRTI.
2) Probably SPD more significantly reflects long-term lung inflammation, while CRP reflects acute injury.
3) Plasma SPD strongly positively correlates with CRP in patients with P.