Abstract
Objective: To study the severity of lung hyperinflation and bone mineral density (BMD) in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods: 120 patients COPD were observed. The investigated group was made by the men with long smoking experience. The average age was 60.2 ± 5.9 years. The Research of function of external breath was studied with multimodular installation of type «Master-Lab/Jaeger». Research of bone mineral density (BMD) was studied with the method x-ray absorbtiometry with the densitometer « Lunar DPX-NT».
Results: The increase of lung volumes such as functional residual capacity (FRC), residual volume (RV), total lung capacity (TLC) shows pulmonary hyperinflation. In patients with COPD of 2nd stage RV% was 176.6 ± 62.37, in patients with COPD of 3rd stage RV% was 226.19 ± 51.63, in patients with COPD of 4th stage RV% was 271.76 ± 60.5 (p<0.05). Maximum TLC% was observed in patients with COPD of 4th stage (131.43 ± 38.9). The study showed a reliably increase in RV/TLC%, the minimum level of RV/TLC% was observed in patients with COPD of 2nd stage (138.51 ± 28.9), the maximum level was in patients with COPD of 4th stage (192.54 ± 34.41). The assessment of BMD showed that BMD of the femoral neck, BMD of trochanter and BMD of hip in patients with COPD of 2nd stage were significantly higher compared with those in patients with COPD of 3rd stage (p<0.05). The correlation coefficient between RV and BMD of hip was -0.38 (p <0.05). Conclusions: in the study the correlation between indicators of hyperinflation and BMD in patients with COPD was proved.